Soloxine

(levothyroxine, thyroxine, thyrozine, thyrosyn) A Drug Used For Treatment Of Hypothyroidism In Dogs And Cats

Soloxine provides thyroid replacement therapy in all conditions of inadequate production of thyroid hormones. Soloxine (Levothyroxine Sodium Tablets, USP) will provide levothyroxine (T4) as a substrate for the physiologic deiodination to liothyronine (T3). Administration of levothyroxine sodium alone will result in complete physiologic thyroid replacement. More details

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Dog Hypothyroidism Medication

Soloxine (levothyroxine sodium, U.S.P.)

Used to treat hypothyroidism in dogs. Provides thyroid replacement therapy in all conditions of inadequate production of hormones produced naturally by the thyroid gland. Lack of thyroid hormone causes hypothyroidism, a common disease of middle age and older dogs.
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Soloxine Information

Generic Name: levothyroxine (leave-oh-thigh-rock’-seen)

Brand Name(s): Levotabs (Vetus), Soloxine (JPI Jones), Synthroid (Knoll), Thyrosyn (Vedco), Thyro-Tabs (Vet-a-Mix)

Indications: Levothyroxine sodium acts, as does endogenous thyroxine, to stimulate metabolism, growth, development and differentiation of tissues. Levothyroxine sodium is absorbed rapidly from the gastrointestinal tract after oral administration. Following absorption, the compound becomes bound to the serum alpha globulin fraction. For purposes of comparison, 0.1 mg of levothyroxine sodium elicits a clinical response approximately equal to that produced by one grain (65 mg) of desiccated thyroid. Soloxine is available in uniquely shaped, color coded tablets in eight different strengths to allow easy and convenient dosage adjustment.

Hypothyroidism is the generalized metabolic disease resulting from deficiency of the thyroid hormones levothyroxine (T4) and liothyronine (T3). Canine hypothyroidism is usually primary, i.e. due to atrophy of the thyroid gland. In the majority of cases the atrophy is associated with lymphocytic thyroiditis and in the remainder it is non-inflammatory and as of yet unknown etiology. Less than 10 percent of cases of hypothyroidism are secondary, i.e. due to deficiency of thyroid stimulating hormone (TSH). TSH deficiency may occur as a component of congenital hypopituitarism or as an acquired disorder in adult dogs, in which case it may be due to the growth of a pituitary tumor.

How this medicine should be used: Soloxine is FDA approved for use in dogs; however, it is a commonly accepted practice for veterinarians to use this medication in cats. The usual dose in dogs is 0.1mg/10 pounds of body weight. The usual dose in cats is 0.05-0.1mg per cat. The dose is maintained by periodic blood tests to determine the T4 level. Animals with hypothyroidism are usually treated with levothyroxine for life.

Special precautions: This medication should not be used in animals allergic to it. Do not use in animals with untreated adrenal insufficiency (Addison’s disease), use with caution in animals with high blood pressure. Use with caution when given with warfarin, theophylline, digoxin, phenytoin and barbiturates. Give 1 hour before or 4 hours after vitamin/mineral combinations containing iron or calcium. Always tell your veterinarian and pharmacist what other medications your pet is taking. There can be differences in the action of levothyroxine when changing brands. As a result, it may be necessary to retest T4 levels when switching brands.