Name(s): Lysodren (Bristol-Myers Squibb)
Mitotane is used in the treatment of Cushings disease in dogs.
Lysodren should be used: Mitotane is not FDA approved
for use in veterinary medicine; however, it is a commonly accepted
practice for veterinarians to use mitotane to treat Cushings
disease in dogs. Mitotane acts by suppressing adrenal gland function
and treatment involves two phases. Lysodren is a cytotoxic drug. It has a predilection for killing cells in a particular zone of the adrenal gland, thereby reducing function of that part of the gland. This lowers the blood cortisol concentration. Mitotane decreases the production of cortisol but at therapeutic doses has minimal effects on other adrenal tissues or hormones such as aldosterone.
Side Effects: Side effects of mitotane may include Addisons
disease or symptoms that indicate the onset of Addisons disease
such as loss of appetite, vomiting, diarrhea , weakness and drowsiness.
There may be a need to supplement with glucocorticoids such as prednisone
if symptoms are observed.