Legend
For Horses
by Bayer
For the treatment of joint dysfunction In Horses
Legend
Equine Joint Treatment, Injectable Solution, 10 mg/ml, 4 ml vial
 Legend
For Horses (hyaluronate sodium) Injectable Solution is
a clear, colorless solution of low viscosity. Legend Injectable
Solution is pyrogen free, sterile and does not contain a preservative.
It is administered by intravenous or intra-articular injection.
Hyaluronic acid, the conjugate acid of hyaluronate sodium, is extracted
from the capsule of Streptococcus spp. and purified, resulting in
a form which is essentially free of protein and nucleic acids. Equine
Legend Injectable Solution is supplied in 2 ml (20 mg) and 4
ml (40 mg) vials. Each ml contains 10 mg hyaluronate sodium, 8.5
mg sodium chloride, 0.223 mg sodium phosphate dibasic and 0.04 mg
sodium phosphate monobasic. The pH is adjusted to between 6.5 and
8.0 with sodium hydroxide or hydrochloric acid.
Chemistry: Hyaluronic
acid, a glycosaminoglycan, can exist in the following forms depending
upon the chemical environment in which it is found: as the acid,
hyaluronic acid; as the sodium salt, sodium hyaluronate (hyaluronate
sodium); or as the hyaluronate anion. These terms may be used interchangeably
but in all cases, reference is made to the glycosaminoglycan composed
of repeating subunits of D-glucuronic acid and N-acetyl-D-glucosamine
linked together by glycosidic bonds. Since this product originates
from a microbial source, there is no potential for contamination
with dermatan or chondroitin sulfate or any other glycosaminoglycan.
Pharmacology:
Hyaluronic acid is a naturally occurring substance present in connective
tissue, skin, vitreous humour and the umbilical cord in all mammals.
High concentrations of hyaluronic acid are also found in the synovial
fluid. It also constitutes the major component of the capsule of
certain microorganisms. The hyaluronic acid produced by bacteria
is of the same structure and configuration as that found in mammals.
The actual mechanism of action for hyaluronate sodium in the healing
of degenerative joint disease is not completely understood. One
major function appears to be the regulation of normal cellular constituents.
This effect decreases the impact of exudation, enzyme release and
subsequent degradation of joint integrity. Additionally, hyaluronate
sodium exerts an anti-inflammatory action by inhibiting the movement
of granulocytes and macrophages. Hyaluronate molecules are long
chains which form a filter network interspersed with normal cellular
fluids. It is widely accepted that injection directly into the joint
pouch enhances the healing of inflamed synovium by restoring lubrication
of the joint fluid. This further supplements the visco-elastic properties
of normal joint fluid.
Contraindications:
There are no known contraindications for the use of Legend®
(hyaluronate sodium) Injectable Solution in horses.
Toxicology:
Legend Injections were administered to normal horses at one,
three and five times the recommended intra-articular dosage of 20
mg and the intravenous dosage of 40 mg. Treatments were given once
weekly for nine consecutive weeks (three times the maximum duration).
No systemic clinical signs were observed nor were there any adverse
effects upon hematology or clinical chemistry parameters. A transient,
slight to mild post-injection swelling of the joint capsule occurred
in some of the animals treated intra-articularly with Equine
Legend Injectable Solution as it did in the saline treated control
horses. No gross or histological lesions were observed in the soft
tissues or the surface areas of the treated joint.
Side Effects
or Adverse Reactions: No local or systemic side effects were observed
in the clinical field trials with either intravenous or intra-articular
injections.
Prescription
Required
Legend
For Horses sold per 4ml
vial: Best
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